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. 2015 Jan 1;142(1):128–139. doi: 10.1242/dev.117887

Fig. 2.

Fig. 2.

Inhibition of non-canonical BMP signaling in K14Cre;pNog tooth. (A) qRT-PCR shows consistently elevated Nog expression levels in K14Cre;pNog tooth germs at E12.5 and E13.5 compared with controls (WT). (B) Representative western blot images and band quantification show significant reduction of P-p38 and P-ERK1/2 but not of P-Smad1/5/8 and P-JNK in K14Cre;pNog tooth germs at E12.5 and E13.5, as compared with controls. *P<0.05, **P<0.01; n=3. (C) Immunofluorescence shows specific inhibition of P-p38 and P-ERK1/2 but not of P-Smad1/5/8 in the epithelium of K14Cre;pNog tooth germs at E13.0. Scale bars: 50 µm.