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. 2015 Jan 1;142(1):128–139. doi: 10.1242/dev.117887

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© 2015. Published by The Company of Biologists Ltd

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Fig. 4. — Attenuated Wnt/β-catenin signaling leads to downregulation of Pitx2 expression in K14Cre;pNog dental epithelium. (A-F) X-gal staining of BAT-gal (A,C,E) and K14Cre;pNog;BAT-gal (B,D,F) tooth germs at E11.5 (A,B), E12.5 (C,D) and E13.5 (E,F). (G,H) X-gal staining of E12.5 BAT-gal molar germs after 1 day organ culture with BSA beads (G) or Nog beads (H). (I-K) Immunofluorescence of active β-catenin in wild type (I), K14Cre,pNog (J) and Nog mutant (K) tooth germs at E13.5. (L-S) In situ hybridization of Pitx2 in E12.5 wild-type molars (L,N) and E12.5 K14Cre;pNog (M,O) molars cultured in the presence or absence of 10 nM LiCl for 2 days. (P-S) In situ hybridization of Pitx2 in K14Cre;pNog (P,R) and K14Cre;pNog;Axin2^+/−(Q,S) molars at E13.5 (P,Q) and E14.5 (R,S). Scale bars: 50 µm.