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. 2015 Jan 1;142(1):128–139. doi: 10.1242/dev.117887

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© 2015. Published by The Company of Biologists Ltd

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Fig. 6. — Genetic rescue of tooth developmental defect in K14Cre;pNog mice by simultaneous activation of Wnt and BMP signaling pathways. (A-F,H-J) H&E staining of molar germs from (A) E14.5 wild type, (B) E14.5 K14Cre;pNog, (C) E14.5 K14Cre;pNog;Axin2^−/−, (D) E14.5 K14Cre;pNog;pcaIB, (E) E14.5 K14Cre;pNog;pcaIB;Axin2^+/−, (F) E16.5 K14Cre;pNog;pcaIB;Axin2^+/−, (H) E14.5 K14Cre;pNog;pPitx2c, (I) E14.5 K14Cre;pNog; pcaIB;pPitx2c and (J) E16.5 K14Cre;pNog;pcaIB;pPitx2c mice. (E′,E″,F′) In situ hybridization of Shh (E′) and Fgf4 (E″) in E14.5 K14Cre;pNog;pcaIB;Axin2^+/− molar germs, and (F′) Pitx2 in E16.5 K14Cre;pNog;pcaIB;Axin2^+/− molar germ. (G) Immunofluorescence of Pitx2 in E14.5 K14Cre;pPitx2c tooth germ and in control (G′). (K) Immunofluorescence of Msx1 in E16.5 K14Cre;pNog;pcaIB;pPitx2c and in control (K′). (L) In situ hybridization of Bmp4 in E16.5 K14Cre;pNog;pcaIB;pPitx2c and in control (L′). Scale bars: 50 µm.