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. 2015 Jan 1;142(1):128–139. doi: 10.1242/dev.117887

Fig. 7.

Fig. 7.

Rescue of cell fate and proliferation defects in K14Cre;pNog mice by activation of BMP and Wnt signaling pathways. (A-D,F-I,K-N,U-X) Immunofluorescence of P-p38 (A-D), P-ERK1/2 (F-I), active β-catenin (K-N) and cyclin D1 (U-X) in E12.5 tooth germs of control and transgenic mice as indicated. (P-S, Z-CC) In situ hybridization of Pitx2 expression (P-S) and BrdU labeling (Z-CC) in E12.5 tooth germs of control and transgenic mice. (L′,V′,AA′) E12.5 K14Cre;pNog tooth germ for comparison. Scale bars: 50 µm. (E,J,O,T,Y) Qualification and statistical comparison for expressions of P-p38 (E), P-ERK1/2 (J), active β-catenin (O), Pitx2 (T) and cyclin D1 (Y). (DD) Statistical comparison of cell proliferation rate (percentage of BrdU-positive cells) in E12.5 molars of control and transgenic mice. *P<0.05, **P<0.01, ***P<0.001; n=3.