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. 2015 Jan 1;142(1):99–107. doi: 10.1242/dev.111161

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© 2015. Published by The Company of Biologists Ltd

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Fig. 4. — Interference with the PCP pathway prevents Shroom-induced apical constriction. Early embryos were animally injected with FLAG-Shroom RNA (50 pg) and other RNAs or MOs as indicated. (A-D) Vangl2 depletion inhibits Shroom-dependent ectopic apical constriction (arrowhead). CO, control. (A-C) Representative embryo images at stage (st) 10.5. (D) Quantification of the data, numbers of embryos with strong, mild and no ectopic constriction are presented. Strong (++) apical constriction involves hyperpigmentation and the accompanying tissue invagination, mild (+) constriction is frequently visible as diffuse hyperpigmentation in the absence of tissue indentation. (E-H) Inhibitory effects of N-Daam1 and zPk1ΔPL on Shroom-dependent apical constriction in stage 10 embryos. (H) Quantification of the data. +indicates ectopic apical constriction; ‘normal’ indicates no constriction.