Fig. 1.
Heterologous prime-boost immunization regimens. Schematic representation of the experimental design that involved five groups of animals given three immunizations 16 wk apart: (1) DNA/EP followed by AdC6 and then AdC7; (2) VV followed by AdC6 and then AdC7; (3) DNA/EP followed by VV and AdC6; (4) DNA/EP followed by VV and AdC7; or (5) three immunizations of AdHu5. Each group included six MamuA*01+ adult Indian RMs. Three to five months following the final immunization all RMs and six additional unvaccinated control animals were challenged with repeated low-dose intrarectal SIVmac239 every week up to 15 times. The times of immunization, challenge, and sample collections are indicated. PB, peripheral blood; RB, rectal biopsy.