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. 2014 Dec 30;112(2):E230–E233. doi: 10.1073/pnas.1423465112

Fig. 1.

Fig. 1.

Effect of Mus given into the hippocampus before or after the extinction training session. Animals were subjected to a CFC task. After 24 h they received intra-CA1 infusion of Veh or Mus (0.01 μg per side) 10 min before (A) or immediately after (B) the Ext Tr of CFC, and then were subjected to a 3-min Ext Test 24 hours later. (A) The retrieval of CFC was blocked by Mus, expressed as a decrease of freezing behavior during the Ext Tr compared with the Veh group, but does not prevent the extinction learning. (B) Animals that received Mus immediately after the Ext Tr expressed the same freezing behavior in the Ext Test as the Veh group. The figure shows the percentage of time spent freezing in the first 2 min of the CFC session, in the first 3 min and last 3 min of the Ext Tr, and in the Ext Test. Data are expressed as mean ± SEM (n = 10–12 animals per group). ***P < 0.001 vs. Veh group in the first 3 min of the Ext Tr, Newman–Keuls test after one-way ANOVA. (Upper) Schematic representation of the behavioral protocol used.