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. 2014 Dec 29;112(2):560–565. doi: 10.1073/pnas.1414569112

Fig. 4.

Fig. 4.

SCV is crucial for RNS evasion. (A) “Redox stress” timeline showing the average normalized 405/480 ratio value of intracellular WT and sifA S. Typhimurium in THP-1 cells for the first 10 h p.i. (B) Intracellular survival of intracellular WT, sifA, sifAsseJ, and sifAsseJ2HAsifA S. Typhimurium in THP-1 cells determined by CFU counts fold change between 2 and 16 h p.i. Each experiment was repeated at least 12 times. (C) The average intrabacterial redox potential in THP-1 cells at 2 and 16 h p.i. Each value represents analysis of more than 15,000 individual cells over three separate experiments. (D) Subset of infected THP-1 cells that contain highly oxidized bacteria. Error bars indicate the SD. Significance was analyzed by a Student t test.