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. 2014 Dec 30;112(2):E204–E213. doi: 10.1073/pnas.1416668112

Fig. 5.

Fig. 5.

The identity of the coagonist is associated to the availability of GluN2A vs. GluN2B subunits at SC–CA1 excitatory synapses. (A) Inhibitory effect of zinc (250–750 nM; orange symbols) and Ro25-6981 (2–4 µM; green symbols) at SC–CA1 synapses throughout development (P9–P10, P12–P14, and P90). Corresponding average NMDA-fEPSP traces are illustrated on Right. (B) Inhibitory effect of RgDAAO (0.2 U/mL; blue symbols) and BsGO (0.2 U/mL; red symbols) during maturation (P9–P10, P12–P14, P22–P23, and P90). Corresponding average NMDA-fEPSP traces are represented on Right. (C) Data from A and B are normalized to the minimal and maximal inhibitory effects. The inhibitory effects of RgDAAO and BsGO are fitted with a sigmoidal dose–response curve (R2 = 0.9539 and 0.9641, respectively). *P < 0.05, **P < 0.01, and ***P < 0.001, using Student t test when comparing with previous developmental stage. All values represent the mean ± SEM.