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. 2014 Dec 15;141(24):4740–4750. doi: 10.1242/dev.112797

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Complementary interactions of Wnt and Hh signaling in the head and GZ. (A-C) Expression of Tc-wg (rows 1 and 2) and Tc-hh (rows 3 and 4) in wild-type (Aa-d) and RNAi-treated embryos with interrupted Wnt (Ba-d) or Hh (Ca-d) signaling in germ rudiments (rows 1 and 3) and elongating germ bands (rows 2 and 4). Anterior is oriented to the left. (Ba-d) When the Wnt pathway was disrupted, both Tc-wg and Tc-hh expression was abolished in Tc-arr^RNAi embryos in the GZ (black arrows) and at the ocular parasegment boundary (black arrowheads). (Ca-d) When the Hh pathway was disrupted, Tc-wg expression was missing in the anterior head of Tc-hh^RNAi embryos (Ca,b, white arrows), and Tc-hh expression was largely present in Tc-smo^RNAi but the anterior head domains appeared enlarged (Cc,d, white arrows). (D) Genetic interactions in the anterior head: Hh signaling acts upstream of Tc-wg. (E) Genetic interactions in the GZ: Wnt/β-catenin acts upstream of Tc-hh and shows autoregulation. Arrows indicate activation. an, antennal stripe; gz, growth zone; oc, ocular stripe.