Table 1.
Patient characteristics
| Variable | Never stopped | Replaced with another drug | Stoppedlong-term | p value |
|---|---|---|---|---|
| Patients | 3,962 | 7,628 | 2,444 | |
| Age, years | 72.5 ± 11.8 | 66.8 ± 11.5 | 67.7 ± 12.4 | <0.0001 |
| Women | 2,364 (59.7) | 4,486 (58.8) | 1,509 (61.7) | <0.0001 |
| Race/Ethnicity | <0.0001 | |||
| White | 3,393 (85.6) | 6,114 (80.2) | 2,022 (82.7) | |
| Black | 171 (4.3) | 470 (6.2) | 152 (6.2) | |
| Hispanic | 187 (4.7) | 491 (6.4) | 124 (5.1) | |
| Asian | 70 (1.8) | 186 (2.4) | 52 (2.1) | |
| Other1 | 141 (3.6) | 367 (4.8) | 94 (3.9) | |
| Health insurance | <0.0001 | |||
| Private | 1,183 (29.9) | 1,890 (24.8) | 614 (25.1) | |
| Public | 2,752 (69.5) | 5,674 (74.4) | 1,810 (74.1) | |
| Other2 | 27 (0.7) | 64 (0.8) | 20 (0.8) | |
| Median income by zip code, USD 1,000 | 57.3 ± 21.5 | 57.2 ± 22.3 | 59.0 ± 23.2 | 0.0015 |
| CKD stage | <0.0001 | |||
| 3A | 2,653 (67.0) | 5,160 (67.7) | 1,547 (63.3) | |
| 3B | 919 (23.2) | 1,744 (22.9) | 605 (24.8) | |
| 4 | 315 (8.0) | 558 (7.3) | 208 (8.5) | |
| 5 | 75 (1.9) | 166 (2.2) | 84 (3.4) | |
| Coronary artery disease | 1,123 (28.3) | 1,755 (23.0) | 522 (21.4) | <0.0001 |
| Diabetes mellitus | 404 (10.2) | 1,293 (15.6) | 268 (11.0) | <0.0001 |
| Hypertension | 2,712 (68.5) | 4,732 (62.0) | 1,487 (60.1) | <0.0001 |
| Cerebrovascular accident | 393 (9.9) | 447 (5.9) | 156 (6.4) | <0.0001 |
| Peripheral vascular disease | 233 (5.9) | 384 (5.0) | 109 (4.5) | 0.032 |
| History of multiple adverse reactions to medications | 1,043 (26.3) | 2,446 (32.1) | 911 (37.3) | <0.0001 |
| Lipid-lowering medication started before 2007 | 264 (6.7) | 1,946 (25.5) | 494 (20.2) | <0.0001 |
| Lipid-lowering medication class | <0.0001 | |||
| Statin | 3,548 (89.6) | 6,563 (86.0) | 1,700 (69.6) | |
| Nonstatin | 181 (4.6) | 905 (11.9) | 677 (27.7) | |
| Combination drug3 | 233 (5.9) | 160 (2.1) | 67 (2.7) | |
| Low-density lipoprotein value, mg/dl | 89.6 ± 32.1 | 97.2 ± 38.3 | 104.9 ± 42.5 | <0.0001 |
| eGFR, ml/min/1.73 m2 | 47.7 ± 13.1 | 49.4 ± 15.1 | 48.2 ± 16.3 | <0.0001 |
Values are given as numbers (%) or means ± SD.
1
Includes unknown.
2
Includes none.
3
A combination of a statin with another lipid-lowering medication.