Table 4.
Association between mismatch repair/BRAF status and clinicopathological factors
|
MMR status
(n = 208) |
BRAF status
(n = 211) |
|||||
| Variable | pMMR | dMMR | P value | Wild type | Mutant | P value |
| Gender | ||||||
| Female | 87 | 16 | 0.800 | 94 | 11 | 0.844 |
| Male | 90 | 15 | 94 | 12 | ||
| Age (yr) | ||||||
| ≤ 50 | 24 | 6 | 0.397 | 29 | 1 | 0.151 |
| > 50 | 153 | 25 | 159 | 22 | ||
| Site | ||||||
| Right-sided | 31 | 11 | 0.037a | 36 | 7 | 0.510 |
| Left-sided | 59 | 12 | 67 | 6 | ||
| Rectum | 84 | 7 | 81 | 10 | ||
| Synchronous lesions | 3 | 1 | 4 | 0 | ||
| Stage | ||||||
| I | 25 | 7 | 0.053 | 30 | 2 | 0.552 |
| II | 55 | 8 | 58 | 7 | ||
| III | 68 | 16 | 73 | 12 | ||
| IV | 29 | 0 | 27 | 2 | ||
| Invasion | ||||||
| No | 99 | 17 | 0.910 | 106 | 12 | 0.701 |
| LVI or PNI or both | 78 | 14 | 82 | 11 | ||
| Differentiation | ||||||
| Well-moderately | 172 | 28 | 0.067 | 180 | 23 | 0.313 |
| Poorly | 5 | 3 | 8 | 0 | ||
| Bowel wall invasion | ||||||
| pT1 | 3 | 1 | 0.511 | 4 | 0 | 0.410 |
| pT2 | 34 | 9 | 39 | 5 | ||
| pT3 | 126 | 18 | 128 | 18 | ||
| pT4 | 14 | 3 | 17 | 0 | ||
| Lymph node metastasis | ||||||
| pN- | 88 | 15 | 0.891 | 96 | 9 | 0.280 |
| pN+ | 89 | 16 | 92 | 14 | ||
| Distant metastasis | ||||||
| No | 148 | 31 | 0.015a | 161 | 21 | 0.456 |
| Yes | 29 | 0 | 21 | 2 | ||
a
P < 0.05 vs control. MMR: Mismatch repair; pT: Pathological tumor stage; pN: Pathological nodal stage; ALI: Angiolymphatic invasion; PNI: Perineural invasion.