Table 2.
Univariate and multivariate analyses of prognostic factors for overall survival of hepatitis B virus-associated intrahepatic cholangiocarcinoma patients included in this study
| Variable | n |
Univariate analysis |
Multivariateanalyses |
||||
| 1-yr | 5-yr | P value | HR | 95%CI | P value | ||
| Gender | 0.205 | NA | NA | NA | |||
| Female | 19 | 66% | 23% | ||||
| Male | 66 | 58% | 10% | ||||
| Age | 0.769 | NA | NA | NA | |||
| ≤ 60 | 59 | 64% | 13% | ||||
| > 60 | 26 | 50% | 12% | ||||
| Capsule formation | 0.522 | NA | NA | NA | |||
| Yes | 32 | 55% | 10% | ||||
| No | 53 | 63% | 14% | ||||
| Cirrhosis | 0.002 | 1.981 | 1.197-3.278 | 0.008 | |||
| Yes | 48 | 56% | 0% | ||||
| No | 37 | 65% | 27% | ||||
| Child-Pugh class | 0.257 | NA | NA | NA | |||
| A | 76 | 61% | 14% | ||||
| B | 9 | 18% | 0% | ||||
| AFP (ng/mL) | 0.342 | NA | NA | NA | |||
| ≤ 20 | 48 | 51% | 11% | ||||
| > 20 | 37 | 72% | 15% | ||||
| CA19-9 (U/mL) | 0.342 | NA | NA | NA | |||
| ≤ 37 | 55 | 66% | 14% | ||||
| > 37 | 30 | 50% | 10% | ||||
| Gross type | 0.402 | NA | NA | NA | |||
| MF | 63 | 61% | 13% | ||||
| PI + IG | 22 | 56% | 11% | ||||
| Differentiation | 0.119 | NA | NA | NA | |||
| Well or Moderate | 63 | 64% | 16% | ||||
| Poor | 22 | 50% | 0% | ||||
| Tumor number | < 0.001 | 2.653 | 1.562-4.508 | < 0.001 | |||
| Single | 60 | 69% | 17% | ||||
| Multiple | 25 | 38% | 0% | ||||
| Tumor size | 0.006 | NA | NA | NA | |||
| < 5 cm | 43 | 70% | 21% | ||||
| ≥ 5 cm | 42 | 49% | 5% | ||||
| LN metastasis | 0.005 | NA | NA | NA | |||
| Yes | 11 | 31% | 0% | ||||
| No | 74 | 64% | 14% | ||||
| Vascular invasion | 0.013 | NA | NA | NA | |||
| Yes | 11 | 24% | 0% | ||||
| No | 74 | 64% | 14% | ||||
| TNM classification | < 0.001 | NA | NA | NA | |||
| Stage I or II | 61 | 66% | 17% | ||||
| Stage III or IV | 24 | 43% | 0% | ||||
| Width of resection margin | 0.274 | NA | NA | NA | |||
| < 1 cm | 37 | 69% | 17% | ||||
| ≥ 1 cm | 48 | 53% | 9% | ||||
| Surgical procedure | 0.962 | NA | NA | NA | |||
| Major hepatectomy | 40 | 61% | 13% | ||||
| Minor hepatectomy | 45 | 59% | 12% | ||||
AFP: Alpha-fetoprotein; CA19-9: Carbohydrate antigen 19-9; MF: Mass-forming; PI: Periductal infiltrating; IG: Intraductal growth; TNM: Tumor-node-metastasis; NA: Not available; HR: Hazard ratio; LN: Lymph node.