Table 4.
Univariate and multivariate analyses of prognostic factors for disease-free survival in hepatitis B virus-associated intrahepatic cholangiocarcinoma patients included in this study
| Variable | n |
Univariate analysis |
Multivariateanalyses |
||||
| 1-yr | 5-yr | P value | HR | 95%CI | P value | ||
| Gender | 0.312 | NA | NA | NA | |||
| Female | 19 | 50% | 0% | ||||
| Male | 66 | 32% | 4% | ||||
| Age | 0.853 | NA | NA | NA | |||
| ≤ 60 | 59 | 33% | 1% | ||||
| > 60 | 26 | 42% | 5% | ||||
| Capsule formation | 0.970 | NA | NA | NA | |||
| Yes | 32 | 40% | 7% | ||||
| No | 53 | 33% | 0% | ||||
| Cirrhosis | 0.003 | 1.919 | 1.153-3.192 | 0.012 | |||
| Yes | 48 | 22% | 0% | ||||
| No | 37 | 52% | 5% | ||||
| Child-Pugh class | 0.237 | NA | NA | NA | |||
| A | 76 | 50% | 20% | ||||
| B | 9 | 27% | 0% | ||||
| AFP (ng/mL) | 0.648 | NA | NA | NA | |||
| ≤ 20 | 48 | 32% | 3% | ||||
| > 20 | 37 | 40% | 2% | ||||
| CA19-9 (U/mL) | 0.189 | NA | NA | NA | |||
| ≤ 37 | 55 | 39% | 3% | ||||
| > 37 | 30 | 29% | 2% | ||||
| Gross type | 0.917 | NA | NA | NA | |||
| MF | 63 | 37% | 3% | ||||
| PI + IG | 22 | 30% | 0% | ||||
| Differentiation | 0.076 | NA | NA | NA | |||
| Well or Moderate | 63 | 42% | 3% | ||||
| Poor | 22 | 18% | 0% | ||||
| Tumor number | < 0.001 | NA | NA | NA | |||
| Single | 60 | 48% | 3% | ||||
| Multiple | 25 | 5% | 0% | ||||
| Tumor size | 0.091 | NA | NA | NA | |||
| < 5 cm | 43 | 44% | 1% | ||||
| ≥ 5 cm | 42 | 27% | 5% | ||||
| LN metastasis | < 0.001 | NA | NA | NA | |||
| Yes | 11 | 0% | 0% | ||||
| No | 74 | 40% | 3% | ||||
| Vascular invasion | 3.779 | 1.601-8.923 | 0.020 | ||||
| Yes | 11 | ||||||
| No | 74 | ||||||
| TNM classification | < 0.001 | NA | NA | NA | |||
| Stage I or II | 61 | 0% | 0% | ||||
| Stage III or IV | 24 | 51% | 20% | ||||
| Width of resection margin | < 0.001 | NA | NA | NA | |||
| < 1 cm | 37 | 49% | 4% | ||||
| ≥ 1 cm | 48 | 0% | 0% | ||||
| Surgical procedure | 0.391 | NA | NA | NA | |||
| Major hepatectomy | 40 | 41% | 2% | ||||
| Minor hepatectomy | 45 | 31% | 3% | ||||
AFP: Alpha-fetoprotein; CA19-9: Carbohydrate antigen 19-9; MF: Mass-forming; PI: Periductal infiltrating; IG: Intraductal growth; TNM: Tumor-node-metastasis; NA: Not available; HR: Hazard ratio; LN: Lymph node.