Table 2.
Sensitivity, specificity, positive and negative predictive value of the different non-invasive examinations for detection of liver cirrhosis
|
All |
Viral hepatitis1 |
|||||||||
| Sensitivity | Specificity | PPV | NPV | P value3 | Sensitivity | Specificity | PPV | NPV | P value3 | |
| Liver stiffness ≥ 13 kPa | 90.4 | 51.4 | 75.2 | 76.7 | 91.3 | 44.4 | 82.5 | 64.0 | ||
| Ultrasound2 | 80.1 | 82.4 | 88.7 | 70.6 | 0.02 | 96.6 | 61.2 | 81.4 | 90.9 | 0.04 |
| Platelets < 150.000/μL | 58.0 | 80.2 | 83.3 | 52.8 | 0.03 | 63.1 | 72.2 | 86.7 | 40.6 | 0.05 |
| Cutaneous liver signs2 | 45.1 | 72.1 | 70.4 | 47.2 | 0.0001 | 42.7 | 64.7 | 77.4 | 28.6 | 0.01 |
| APRI-Score ≥ 2 | NA | NA | NA | NA | NA | 56.1 | 63.3 | 87.7 | 24.1 | |
1
n = 139; only patients with chronic hepatitis B, C and D were included;
2
According to the definitions in the patients and methods section; available for 257 patients;
3
For comparison of sensitivities with liver stiffness as reference. NA: Not applicable; PPV: Positive predictive value; NPV: Negative predictive value.