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. 2014 Dec 16;11:24. doi: 10.1186/s12979-014-0024-6

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© Harrison et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Aged HET3 mice are more susceptible to M. tuberculosis than young. M. tuberculosis infected old (N = 40) and young (N = 18), female HET3 mice were euthanized when morbidity developed. Survival (A), weights over time in old (B) and young (C) mice, peak body weight (D), weight at euthanasia (E), and proportional weight loss (F) are shown. Survival data were analyzed by Log rank test, ****p < 0.0001. Pairwise data were analyzed by Student’s t-tests, *p < 0.05, **p < 0.01. Data were censored for 11 old mice due to non-TB morbidity. No data from young mice were censored.