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. 2014 Dec 16;11:24. doi: 10.1186/s12979-014-0024-6

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© Harrison et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Oral rapamycin does not improve survival of M. tuberculosis infected aged mice and minimally impacts lung lesions. Rapamycin treated (N = 37) and untreated (N = 13) old HET3 mice were infected with aerosolized M. tuberculosis and euthanized when removal criteria were met (A). Lung sections were semi-quantitatively evaluated for necrosis, neutrophils, and lymphocytes, and the proportion of mice was determined for each category (B). Examples of the microscopic lesions are shown, magnified 200 times: necrosis (C); neutrophils (D); lymphocytes (E).