Table 2.
Pattern and treatment of recurrences
| R0 (n = 214) | R1 (n = 59) | P | |
|---|---|---|---|
| No recurrence | 75 (35%) | 14 (23.7%) | 0.101 |
| Recurrence | 139 (65%) | 45 (76.3%) | |
| Site of recurrence(s) | |||
| Hepatic | 45 (32.4%) | 19 (42.2%) | |
| Extra hepatic | 50 (36.0%) | 13 (28.9%) | 0.465 |
| Both | 44 (31.6%) | 13 (28.9%) | |
| Time to recurrence (months) | 27.8 ± 28.4 | 20.8 ± 27.5 | 0.029 |
| Hepatic recurrence | 89 (41.6%) | 32 (54.2%) | 0.083 |
| Surgical margin | 12 (13.4%) | 10 (31.3%) | 0.025 |
| First recurrence curative treatment (analysis by patient) | 63 (45.3%) | 16 (35.6%) | 0.250 |
| First hepatic recurrence curative treatment (analysis by site) | |||
| Iterative hepatectomy | 33 (37.1%) | 8 (25%) | 0.216 |
| Including surgical margin recurrence | 6 (6.7%) | 2 (6.2%) | 0.156 |
| Radiofrequency | 2 (2.2%) | 4 (12.5%) | 0.042 |
| Including surgical margin recurrence | 1 (8.3%) | 2 (20%) | 0.429 |
| First extra-hepatic recurrence curative treatment (analysis by site) | |||
| Surgery | 30 (31.9%) | 4 (15.4%) | 0.098 |
| Radiofrequency | 1 (1.1%) | 4 (15.4%) | 0.008 |
| Status at last follow up | |||
| Dead | 82 (38.3%) | 32 (54.2%) | 0.028 |
| Alive without recurrence | 67 (31.3%) | 11 (18.6%) | 0.057 |
| Alive without disease (including iterative curative treatment of recurrence) | 101 (47.2%) | 21 (35.6%) | 0.112 |
| Overall survival (months) | 44.6 ± 28.5 (1–133) | 38.8 ± 30.3 (1–122) | 0.050 |
Data were expressed as the mean ± standard deviation; Results with borderline or statistical significance were indicated in bold.