. 2014 Jul 9;17(2):176–184. doi: 10.1111/hpb.12316

Table 3.

Univariate (UV) and multivariate (MV) analysis of 5-year overall (OS), disease-free (DFS) and progression-free (PFS) survivals

	n	OS (%)	UV (P-value)	MV (P-value) HR [95%CI]	DFS (%)	UV (P-value)	MV (P-value) HR [95%CI]	PFS (%)	UV (P-value)	MV (P-value) HR [95%CI]
All patients	273	51			28			46
≥70 years	203	47	0.199		29	0.569		45	0.670
<70 years	70	52	0.199		27	0.569		45	0.670
ASA ≤2	234	52	0.424		26	0.085		45	0.828
ASA >2	39	42	0.424	42	41	0.085			0.828
Colon	204	55	0.118	0.054	32	0.008	NS	50	0.015	0.013
Rectum	69	40	0.118	1.5 [0.99–2.2]	18	0.008	NS	33	0.015	1.6 [1.1–2.4]
CEA
<10	138	57	0.140		30	0.649		54	0.168
≥10	135	44	0.140		27	0.649		41	0.168
Chemo
Neoadjuvant	176	47	0.042	NS	39	0.001	NS	52	0.003	NS
No	97	57	0.042	NS	22	0.001	NS	40	0.003	NS
Adjuvant	158	58	0.006	0.048	25	0.889		49	0.219
No	115	41	0.006	0.6 [0.4–0.9]	31	0.889		41	0.219
Peri-operative	233	51	0.662		25	0.026	NS	45	0.376
No	40	46	0.662		30	0.026	NS	50	0.376
Hepatectomy
Major	170	55	0.209		26	0.183		42	0.246
Minor	103	48	0.209		30	0.183		50	0.246
≥5 seg	38	53	0.003	NS	15	0.003	NS	28	0.001	NS
<5 seg	235	35	0.003	NS	30	0.003	NS	47	0.001	NS
Operative time			0.037	NS		0.160			0.064
Blood loss			0.004	NS		0.019	NS		0.002	NS
Transfusion	11	40	0.087		0	0.002	NS	15	0.001	NS
No	262	50	0.087		29	0.002	NS	44	0.001	NS
Complication	106	43	0.007	NS	24	0.442		35	0.082	NS
No	167	56	0.007	NS	29	0.442		50	0.082	NS
Unilobar	220	50	0.990		30	0.135		44	0.212
Bilobar	53	50	0.990		18	0.135		55	0.212
Stage T1 or T2	30	62	0.160		33	0.276		55	0.210
Stage T3 or T4	233	49	0.160		27	0.276		43	0.210
Stage
N0	128	63	0.008	0.008	39	0.005	NS	56	0.005	0.046
N+	145	44	0.008	1.7 [1.1–2.7]	20	0.005	NS	38	0.005	1.4 [1.1–2.1]
Stage
M0	118	49	0.160		35	0.002	NS	52	0.012	NS
M1	155	54	0.160		22	0.002	NS	40	0.012	NS
Time interval of CLM occurrence			0.075	NS		0.001	0.005		0.004	0.038
Time interval of CLM occurrence			0.075	NS		0.001	0.6 [0.3–0.8]		0.004	0.6[0.6–0.9]
Number of CLM			0.001	0.003		0.001	0.006		0.001	0.018
Number of CLM			0.001	1.1 [1.1–1.2]		0.001	1.1 [1.1–1.1]		0.001	1.1 [1.1–1.1]
Size of larger metastasis			0.001	0.001		0.001	0.006		0.001	0.003
Size of larger metastasis			0.001	1.1 [1.1–1.2]		0.001	1.1 [1.1–1.2]		0.001	1.1 [1.1–1.2]
Margin
R1	59	39	0.010	NS	15	0.025	NS	33	0.037	NS
R0	214	54	0.010	NS	31	0.025	NS	47	0.037	NS
<10 mm	142	58	0.940		27	0.475		46	0.871
≥10 mm	72	49	0.940		35	0.475		48	0.871
<4 mm	94	46	0.715		24	0.460		47	0.813
≥4 mm	120	57	0.715		34	0.460		46	0.813

Differences in survival between the R0 and R1 groups were estimated using Cox's proportional hazards model and expressed as hazard ratios (HR) with 95% confidence (CI); Results with borderline or statistical significance were indicated in bold. NS, non significant (by multivariate analysis).