Figure 3.

Structural plasticity of inhibitory synapse in a neuronal network during homeostasis. Increased network activity leads to reduced postsynaptic density on the excitatory neuron and increased synapses and spouting on the inhibitory neuron through connections to the excitatory neuron; conversely, decreased network activity leads to increased postsynaptic density on the excitatory neuron and reduced inhibitory elements on the inhibitory neuron. This diagram is based on the homeostatic network theory and is inspired by the schematics from Turrigiano and Nelson (2004); Butz et al. (2009b) and Gambino and Holtmaat (2012).