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. 2014 Oct 7;136(5):E252–E261. doi: 10.1002/ijc.29217

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© 2014 The Authors. Published by Wiley Periodicals, Inc. on behalf of UICC.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Neuroblastoma PDXs exhibit wide-spread metastasis to distant organs including bone marrow. High numbers of NCAM-positive metastatic cells were found in lungs, liver, ipsilateral kidney and bone marrow of PDXs (7–9 sections from each PDX model). Bone marrow metastases were dividing as shown by Ki-67 expression (inserted field). In contrast, orthotopic SK-N-BE(2)c xenografts (n = 8) exhibited only low numbers of metastatic cells in liver and lungs and no cells in bone marrow. The shown pictures are representative for the mice. Scale bar is 100 µm in PDX lung, liver and ipsilateral kidney, and 50 µm in the PDX bone marrow and SK-N-BE(2)c lung and liver.