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. 2014 Aug 28;10(8):748. doi: 10.15252/msb.20145136

Figure 6. Genome-wide analysis of human translation initiation efficiency.

Figure 6

  1. Distribution of the initiation efficiencies for the entire TIS sequence space (i.e., all permutations of the motif NNNNNNAUGNN).
  2. Distribution of initiation efficiencies for all annotated human TISs.
  3. Distribution of TIS efficiencies for all human uORF TISs (i.e., AUG start codons located in 5′ UTRs). Distribution of efficiencies for all TIS sequences included for comparison (dashed-line, B and C). Efficiency values were predicted with the dinucleotide PWM. A value of 100 corresponds to the TIS efficiency of GCCACCAUGGG.