Table 1.

Associations between Preoperative Body Mass Index and 1-Year Mortality after Lung Transplantation

	Body Mass Index Category
	Underweight	Normal	Overweight	Obese
				Class I	Class II–III
No.	900	3,645	3,151	1,270	107
Years of follow-up, median (IQR)	2.1 (1.1–3.9)	2.3 (1.1–4.0)	2.4 (1.0–4.0)	2.1 (1.0–4.0)	1.9 (0.6–3.5)
No. of decedents	160	542	527	226	28
Person-years	795.0	3276.8	2774.3	1102.6	84.5
1-yr mortality rate per 100 person-years (95% CI)	20.1 (17.2–23.5)	16.5 (15.2–18.0)	19.0 (17.4–20.7)	20.5 (18.0–23.4)	33.2 (22.9–48.0)
Hazard ratios (95% CI)
Unadjusted	1.21 (1.01–1.45)	1	1.14 (1.01–1.29)	1.23 (1.06–1.44)	1.95 (1.33–2.85)
Model 1	1.37 (1.12–1.67)	1	1.05 (0.93–1.20)	1.07 (0.91–1.27)	1.85 (1.26–2.70)
Model 2	1.34 (1.09–1.66)	1	1.06 (0.93–1.21)	1.08 (0.91–1.28)	1.90 (1.30–2.77)
Model 3	1.35 (1.10–1.66)	1	1.05 (0.92–1.20)	1.08 (0.91–1.27)	1.90 (1.29–2.78)

Definition of abbreviations: CI = confidence interval; IQR = interquartile range.

Data derived from the Organ Procurement and Transplantation Network cohort of 9,073 lung transplant recipients transplanted between May 4, 2005 and June 14, 2011.

Body mass index (BMI) categories: underweight (BMI < 18.50), normal (BMI 18.50–24.99), overweight (BMI 25.00–29.99), obese class I (BMI 30.00–34.99), obese class II–III (BMI ≥ 35.00).

Model 1: Adjusted for recipient factors: age, sex, height, previous cardiac surgery, lung allocation score, center,* diagnosis (chronic obstructive pulmonary disease includes α₁-antitrypsin disease),* previous lung transplantation,* mechanical ventilation.*

Model 2: Model 1 + adjustment for donor factors: age, sex, height, BMI, arterial partial pressure of oxygen, alcohol use, smoking history, pulmonary infection, cause of death, diabetes,* donor-recipient height interaction, donor-recipient sex interaction.

Model 3: Model 2 + adjustment for procedural factors: ischemic time, transplant type.

^*Included in the model as stratification variable.