Figure 2.

Increased matrix metalloproteinase (MMP) 19 gene expression in non–small cell lung cancer portends a worse prognosis. Overall survival analysis by Kaplan-Meier curves of MMP19 microarray gene expression levels in lung adenocarcinoma tissue obtained from 408 subjects from the Director’s Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma (A) and 46 non–small cell lung cancer subjects obtained from the University of Pittsburgh (B). Adjusted overall survival differences in the (C) Challenge cohort (adjusted for age, sex, adjuvant chemotherapy, and radiotherapy) and (D) Pitt cohort (adjusted for age, sex, adjuvant chemotherapy, and radiotherapy as well as intraoperative brachytherapy). Blue line = patients with MMP19 microarray expression levels above the median value. Green line = patients with MMP19 microarray expression levels below the median value. Dotted black lines = the median survival in months for both groups.