. 2014 Oct 1;190(7):722–732. doi: 10.1164/rccm.201406-1101PP

Table 2.

Toll-like Receptor Polymorphism and Susceptibility to Bacterial Lung Infection in Humans

	Polymorphism	Pathogens Studied	Host Response (Pulmonary) to Infection	Reference
TLRs
TLR2	Arg753Gln	Staphylococcus aureus	No impact	41
TLR2	Arg753Gln	Mycobacterium tuberculosis	Susceptible	42
TLR4	D299G and T399I	Gram-negative bacteria	Susceptible	45
TLR4	D299G and T399I	Legionella pneumophila	Resistance	46
TLR5	Stop codon SNPs (1174T and 1775G)	Legionella pneumophila	Susceptible	47
TLR5	1174C > T	Burkholderia pseudomallei	Resistance	48
TLR6	rs5743808 (359T > C)	Legionella pneumophila	Susceptible	76
TLR9	rs352139 (A > G)	Mycobacterium tuberculosis	Susceptible	77
TLR signaling molecules
MyD88	In-frame MYD88 deletion or missense mutations	Streptococcus pneumoniae	Susceptible to pyogenic infections (ND)	50
		Staphylococcus aureus
		Pseudomonas aeruginosa
IRAK-4	Deletion (82IdelT) or substitution (O293X) in IRAK-4	Streptococcus pneumoniae	Susceptible to pyogenic infections (ND)	49
IRAK-4	Deletion (82IdelT) or substitution (O293X) in IRAK-4	Staphylococcus aureus	Susceptible to pyogenic infections (ND)	49
TRIF/Mal
	TIRAP S180L	Streptococcus pneumoniae	Protective to invasive pneumococcal disease and tuberculosis	78
	TIRAP S180L	Mycobacterium tuberculosis		78

Definition of abbreviations: ND = not determined; SNP = single-nucleotide polymorphism; TIRAP = Toll-IL-1R domain-containing adapter protein; TLR = Toll-like receptor; TRIF = TIR-domain–containing adapter-inducing IFN-β.