Table 1.
Clinical Characteristics of Study Cohort
| HIV+COPD− (n = 13) | HIV+COPD+ (n = 14) | HIV−COPD+ (n = 7) | |
|---|---|---|---|
| Age | 48.2 (10.5) | 51.2 (7.8) | 50.6 (7.3) |
| African American, n (%) | 11 (85) | 14 (100) | 7 (100) |
| Male, n (%) | 10 (77) | 12 (86) | 4 (57) |
| Current smoker, n (%) | 9 (69) | 9 (64) | 9 (100) |
| Pack-years smoked, median (IQR) | 8.45 (2.2–22.5) | 13.4 (7.2–30) | 18.7 (13.6–35.9) |
| FEV1/FVC ratio | 0.78 (0.04) | 0.56 (0.10)* | 0.63 (0.05)* |
| FEV1 | |||
| Absolute, L | 2.84 (0.63) | 1.92 (0.76)† | 2.00 (0.63)† |
| % Predicted | 89.5 (13) | 62.6 (20)* | 78.0 (20) |
| Plasma viral load | |||
| Undetectable, n (%) | 9 (69) | 10 (71) | |
| Copies/ml, median (IQR)‡ | 30,779 (1,717–58,122) | 18,492 (7,552–40,252) | — |
| Antiretroviral use, n (%) | 9 (69) | 11 (79) | — |
| Blood CD4 | |||
| Less than 200, n (%) | 2 (15) | 3 (21) | — |
| Cells/cm3, median (IQR) | 485 (427–551) | 352 (293–609) |
Definition of abbreviations: COPD = chronic obstructive pulmonary disease; IQR = interquartile range.
All values mean (SD) unless otherwise indicated.
P value versus HIV+COPD− participants: *P < 0.001, †P < 0.01.
‡
Among detectable viral load.