Table 1.
Chromosomal aberrations and Sister Chromatid Exchanges (SCEs) in bone marrow cells of mice treated with empty liposomes or Cyclophosphamide (CYP) or CYP encapsulated in liposomes
| Groups | Sampling time (h) | Number of metaphases analyzed | Cells with chromatid breakage (%) | Cells with centric fusions (%) | Cells with centromeric attenuation (%) | Cells with end to end association (%) | Total a Aberrations (%) | SCEs / Cell a |
|---|---|---|---|---|---|---|---|---|
| G1 (Negative Control) | 24 | 250 | 2.20 | 0.20 | - | - | 2.40 + 1.496 | 4.20 + 0.374 |
| G2 (Empty lipo.) | 24 | 250 | 2.00 | - | - | - | 2.00 + 1.265 | 4.60 + 0.400 |
| G3 (CYP) | 24 | 250 | 44.40 | 6.40 | 1.20 | 3.20 | 55.20 + 6.997 | 6.85 + 0.374 |
| 48 | 250 | 28.60 | 3.40 | 0.40 | 1.20 | 33.60 + 4.271 | 7.15 + 0.489 | |
| 72 | 250 | 21.60 | 2.40 | - | 0.80 | 24.80 + 4.118 | 6.80 + 0.245 | |
| G4 (CYP+ Lipo.) | 24 | 250 | 37.20 | 3.40 | - | 3.40 | 44.00 + 4.382 | 8.05 + 0.548 |
| 48 | 250 | 34.80 | 1.80 | 1.40 | 4.40 | 42.40 + 4.964 | 7.70 + 0.245 | |
| 72 | 250 | 28.00 | 3.20 | 2.00 | 3.60 | 36.80 + 4.118 | 8.80 + 0.244 |
a
Values represent mean + S.E. of five animals
Empty lipo. = Empty liposomes
CYP+ Lipo. = CYP encapsulated in liposomes