Table 2.
Incidence of aberrant cells %, mitotic index, replication index and average generation time of mice bone marrow cells treated with cyclophosphamide free or encapsulated in liposomes
| Groups | Sampling time (h) | Incidence of aberrant cells a (%) | Mitotic index a | Replication index a | Average generation time a |
|---|---|---|---|---|---|
| G1 (Negative Control) | 24 | 2.40 + 0.244 | 85.84 + 0.748 | 1.76 + 0.158 | 11.23 + 0.268 |
| G2 (Empty lipo.) | 24 | 2.00 + 0.447 | 83.29 + 0.836 | 1.73 + 0.144 | 11.89 + 0.259 |
| G3 (CYP) | 24 | 38.00 + 1.363 | 46.47 + 0.860 | 1.47 + 0.181 | 14.25 + 1.183 |
| 48 | 22.40 + 0.836 | 56.94+ 0.927 | 1.54 + 0.170 | 13.80 + 0.780 | |
| 72 | 17.20 + 1.816 | 50.66 + 0.583 | 1.65 + 0.037 | 12.20 + 0.200 | |
| G4 (CYP+ Lipo.) | 24 | 32.60 + 1.113 | 42.10 + 0.871 | 1.63 + 0.153 | 12.58 + 0.245 |
| 48 | 30.00 + 0.663 | 36.16 + 0.707 | 1.54 + 0.046 | 12.82 + 0.244 | |
| 72 | 25.40 + 1.593 | 39.10 + 0.663 | 1.46 + 0.025 | 14.20 + 0.374 |
a
Values represent mean + S.E. of five animals