Figure 7.

Mediators released by hyperplastic alveolar epithelial cells were suppressed by deoxycytidine kinase (DCK) inhibition. Real-time polymerase chain reaction was performed to examined the transcript levels of cytokines and receptors in total RNA isolated from the whole lung at Day 33, including monocyte chemoattractant protein-1 (MCP-1), C-C chemokine receptor type 2 (CCR2), matrix metalloproteinase (MMP) 13, MMP7, and epidermal growth factor receptor (EGFR). 18S ribosomal RNA (rRNA) was used as an internal control. n = 4 for bleomycin-negative lungs, and n = 8 for bleomycin-positive lungs. *P < 0.05 versus Bleo⁻dyc⁻ mice, ^#P < 0.05 versus Bleo⁺dyc⁻ mice. Bleo = bleomycin; dyC = deoxycytidine.