Figure 4. Mean connectivity (A), betweenness (B) and closeness centrality (C) for proteins undergoing deleterious variants.

• A–C The purple line represent deleterious variants in both alleles (homozygosis) and the green line deleterious variants in at least one allele (homozygosis+heterozygosis), grouped according to the number of individuals in normal populations (1,000 genomes and Spanish populations) in which they were observed. The red line represents CLL somatic heterozygous deleterious variants observed in growing number of individuals (within the sample of patients). The plots include 1SD bars. Error bars indicate the dispersion of values observed across the individuals analysed.