Table 2.

Spearman's rank correlation coefficient (ρ) between the number of interactions, the betweenness and the closeness centrality with respect to the frequency of occurrence of deleterious variants in the population in three different scenarios: homozygosis, heterozygosis and the somatic mutations observed in the CLL patients

	Number of interactions		Betweenness		Closeness centrality
	ρ	P-value	ρ	P-value	ρ	P-value
Homozygosis	−0.0391	0.101	−0.0341	0.154	−0.0238	0.319
Heterozygosis	−0.0661	1.34 × 10−7	−0.0534	2.053 × 10−5	−0.0536	1.934 × 10−5
CLL somatic	0.152	0.0116	0.118	0.051	0.128	0.0335