Table 3.

Validation of the relationship between the module centrality and damage using different network module detection algorithms (Infomap and Walktrap) and three protein interactomes (see Materials and Methods)

Sample	Interactome	Network module detection algorithm	Rho	P-value
1,000 genomes, MGP1 and germinal CLL	Curated	Walktrap	−0.292	≤ 0.001
	Curated	Infomap	−0.159	≤ 0.001
	Non-Curated	Walktrap	−0.13	0.28
	Non-Curated	Infomap	−0.11	≤ 0.01
	STRING	Walktrap	−0.186	≤ 0.01
	STRING	Infomap	−0.205	≤ 0.01
Somatic variants CLL	Curated	Walktrap	0.192	≤ 0.01
	Curated	Infomap	0.176	≤ 0.001
	Non-Curated	Walktrap	0.321	≤ 0.01
	Non-Curated	Infomap	0.211	≤ 0.01
	STRING	Walktrap	0.28	≤ 0.00
	STRING	Infomap	0.322	≤ 0.001