Table 3.

Identification of candidate genes by whole exome sequencing

	Patient I		Patient II
	Variants	Genes	Variants	Genes
Total	124,631	15,978	129,098	16,015
Genes encoding mitochondrial protein	1698	671	1882	681
Allele frequency <3%	98	94	100	86
Predicted deleterious	32	27	18	18
Recessive pattern of inheritance	1	1	2	1