Table 3.
Analysis of covariance (ANCOVA) between MMSE-derived impairment groups at screening and baseline,controlling for age and education
| Scale/Test | Mild Disease (N=136) | Moderate Disease (N=108) | ANCOVA | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Mean | SE | Mean | SE | μmod-μmild | SDpooled | Effect Size* | F-Statistic | P-value | |
| Disability Assessment for Dementia | 84.2 | 1.42 | 68.3 | 1.61 | -15.9 | 16.02 | -0.99 | 53.72 | < 0.001 |
| Clinical Dementia Rating-SOB | 4 | 0.2 | 6.4 | 0.23 | 2.4 | 2.27 | 1.06 | 60.83 | < 0.001 |
| Mini-Mental State Exam | 22.9 | 0.18 | 15.9 | 0.2 | -6.9 | 2 | -3.48 | 658.6 | < 0.001 |
| Dependence Scale | 4.6 | 0.17 | 6.3 | 0.2 | 1.8 | 1.96 | 0.9 | 43.77 | < 0.001 |
| Neuropsychiatric Inventory | 7.3 | 0.89 | 8.6 | 1 | 1.3 | 9.99 | 0.13 | 0.97 | 0.327 |
| NPI Caregiver Distress | 3.6 | 0.45 | 4.8 | 0.51 | 1.2 | 5.09 | 0.23 | 2.97 | 0.086 |
| ADAS-Cog | 16.2 | 0.62 | 27 | 0.7 | 10.9 | 6.94 | 1.57 | 134.04 | < 0.001 |
| NTB-Executive Function | -1 | 0.05 | -1.6 | 0.05 | -0.6 | 0.53 | -1.09 | 65.23 | < 0.001 |
| NTB-Memory | -2 | 0.07 | -2.9 | 0.08 | -0.9 | 0.78 | -1.18 | 76.08 | < 0.001 |
| Total NTB Score | -1.6 | 0.05 | -2.4 | 0.06 | -0.8 | 0.6 | -1.36 | 100.12 | < 0.001 |
*
Effect size is defined as the absolute value of Cohen’s d; d=[mean difference]/[pooled SD].