Table 4.
Classification of change from baseline to week 78, based on regression based change scores incorporating age, gender, education, region, and baseline score
| Healthy Controls | AD group | P-valuea | P-valueb | |
|---|---|---|---|---|
| ADAS-Cog | ||||
| Improved | 1 (2%) | 0 | < 0.001 | < 0.001 |
| Unchanged | 45 (92%) | 35 (16%) | ||
| Worsened | 3 (6%) | 178 (84%) | ||
| MMSE | ||||
| Improved | 1 (2%) | 3 (1%) | < 0.001 | < 0.001 |
| Unchanged | 45 (92%) | 25 (11%) | ||
| Worsened | 3 (6%) | 191 (87%) | ||
| DAD | ||||
| Improved | 0 | 20 (9%) | < 0.001 | < 0.001 |
| Unchanged | 46 (94%) | 12 (5%) | ||
| Worsened | 3 (6%) | 187 (85%) | ||
| DS | ||||
| Improved | 2 (4%) | 11 (5%) | < 0.001 | < 0.001 |
| Unchanged | 45 (92%) | 22 (10%) | ||
| Worsened | 2 (4%) | 186 (85%) | ||
| NPI | ||||
| Improved | 1 (2%) | 55 (25%) | < 0.001 | < 0.001 |
| Unchanged | 46 (94%) | 60 (27%) | ||
| Worsened | 2 (4%) | 104 (47%) | ||
| NPI Caregiver | ||||
| Improved | 0 | 44 (20%) | < 0.001 | 0.005 |
| Unchanged | 44 (90%) | 82 (37%) | ||
| Worsened | 5 (10%) | 93 (42%) | ||
| CDR-SB | ||||
| Improved | 0 | 22 (10%) | < 0.001 | < 0.001 |
| Unchanged | 47 (96%) | 16 (7%) | ||
| Worsened | 2 (4%) | 181 (83%) | ||
| NTB-Memory | ||||
| Improved | 3 (6%) | 0 | < 0.001 | < 0.001 |
| Unchanged | 42 (86%) | 73 (34%) | ||
| Worsened | 4 (8%) | 143 (66%) | ||
| NTB-Executive Function | ||||
| Improved | 2 (4%) | 0 | < 0.001 | 0.016 |
| Unchanged | 44 (90%) | 90 (42%) | ||
| Worsened | 3 (6%) | 126 (58%) | ||
| Total NTB | ||||
| Improved | 4 (8%) | 1 (< 1%) | < 0.001 | 0.003 |
| Unchanged | 42 (86%) | 60 (28%) | ||
| Worsened | 3 (6%) | 155 (72%) |
a
Chi-squared tests comparing the change from baseline to 78 weeks between AD participants and healthy controls;
b
Difference between groups over time using GEE.