Table 5.

Mean change from baseline to Week 78 within healthy control group and Alzheimer’s disease group, adjusted for baseline score, tested against a null hypothesis value of 0

Group/Assessment	Mean change from baseline	SE	Responsiveness indexa	P-valueb	P-valuec
ADAS-Cog
Control, Normal Cognition	2.992	1.394	1.27	0.033	0.588
Mild-Moderate Alzheimer’s	3.866	0.569		< 0.001
MMSE
Control, Normal Cognition	-1.132	0.678	-1.88	0.096	0.168
Mild-Moderate Alzheimer’s	-2.217	0.263		< 0.001
DAD
Control, Normal Cognition	1.216	2.339	-22.31	0.604	< 0.001
Mild-Moderate Alzheimer’s	-11.884	1.021		< 0.001
DS
Control, Normal Cognition	-0.856	0.305	2.94	0.005	< 0.001
Mild-Moderate Alzheimer’s	1.123	0.115		< 0.001
NPI
Control, Normal Cognition	-1.781	1.452	2.3	0.221	0.001
Mild-Moderate Alzheimer’s	3.513	0.668		< 0.001
NPI caregiver
Control, Normal Cognition	-0.448	0.77	1.8	0.561	0.008
Mild-Moderate Alzheimer’s	1.84	0.354		< 0.001
CDR-SB
Control, Normal Cognition	0.036	0.378	16.5	0.924	< 0.001
Mild-Moderate Alzheimer’s	1.647	0.15		< 0.001
NTB-Memory
Control, Normal Cognition	0.592	0.103	-0.14	< 0.001	< 0.001
Mild-Moderate Alzheimer’s	-0.126	0.037		< 0.001
NTB-Executive Function
Control, Normal Cognition	0.198	0.077	-0.58	0.011	< 0.001
Mild-Moderate Alzheimer’s	-0.311	0.032		< 0.001
Total NTB
Control, Normal Cognition	0.332	0.086	-0.42	< 0.001	< 0.001
Mild-Moderate Alzheimer’s	-0.157	0.031		< 0.001

^aThe responsiveness index is a measure of effect size calculated as the mean change in the Alzheimer’s disease groups divided by the standard deviation of the change scores in the healthy control group;

^b P value of the mean change within group different from baseline;

^c P value of the difference between groups.