Table 2.

Anatomical distribution of reduced glucose metabolism for in MAPT intron 10 +3 carriers relative to non-carriers

			MNI Coordinates
Location	BA	T-value	x	y	z	p-value
L. Inferior Frontal Gyrus	47	4.58	-26	10	-18	0.000
L. Inferior Parietal Lobule	40	3.11	-58	-32	46	0.004
L. Middle Frontal Gyrus	10	3.38	-26	66	12	0.002
	6	2.92	-46	10	50	0.005
	9	3.03	-52	26	34	0.004
L. Middle Temporal Gyrus	21	3.29	-56	2	-18	0.002
		2.98	-64	-10	-12	0.005
		2.68	-58	-18	-6	0.009
L. Superior Frontal Gyrus	10	2.83	-36	48	32	0.006
	6	3.55	-20	6	70	0.001
		3	-8	28	66	0.004
	8	3.96	-6	44	52	0.001
		3.13	-22	32	56	0.003
L. Superior Parietal Lobule	7	3.34	-28	-58	64	0.002
L. Superior Temporal Gyrus	10	4.77	-14	70	18	0.000
	38	3.85	-22	14	-34	0.001
L. Thalamus		3.22	-8	-32	-4	0.003
L. Uncus	34	4.42	-18	2	-22	0.000
R. Anterior Cingulate	32	3.71	2	46	6	0.001
R. Caudate Body		3.98	16	22	16	0.001
		3.57	14	12	20	0.001
R. Medial Frontal Gyrus	25	5.29	8	6	-22	0.000
R. Middle Frontal Gyrus	8	3.1	40	24	56	0.004
R. Middle Temporal Gyrus	21	3.92	64	-6	-12	0.001
R. Postcentral Gyrus	7	3.16	16	-52	72	0.003
R. Superior Frontal Gyrus	10	4.66	22	68	14	0.000
		4.1	16	62	28	0.000
	6	3.11	14	32	60	0.004
	8	2.94	20	38	52	0.005
R. Superior Parietal Lobule	7	3.47	18	-68	58	0.002
R. Superior Temporal Gyrus*	38	5.99	44	16	-22	0.000
R. Uncus	34	4.57	20	4	-22	0.000

BA = Brodmann area; MNI = Montreal Neurologic Institute; L. = left; R. = right. p < 0.01, uncorrected.

^*Significant cluster for p < 0.05 at FWE-corrected.