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. 2014 Dec 24;14:363. doi: 10.1186/s12888-014-0363-z

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© Päären et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The receiver operating characteristic (ROC) curve of adult bipolar disorder (compared with no mood episodes in adulthood) among adolescents with mood disorders, according to the number of five independent child and adolescent risk factors. The following risk factors were included: disruptive disorders; feelings of worthlessness; multiple somatic symptoms; long-term depression; 1st and/or 2nd degree family histories of bipolar disorder. The presence of at least two risk factors resulted in a sensitivity of 68% and specificity of 72%, whereas the presence of three or more risk factors resulted in sensitivity of 52% and specificity of 88%.