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. 2014 Dec 6;14:105. doi: 10.1186/s12896-014-0105-9

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© Yamaguchi et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Healing of rat calvarial defects assessed by micro-computed tomography. (A) Micro-computed tomography (micro-CT) images of the calvaria, 0, 2, and 4 weeks after implantation of the indicated materials. Newly regenerated bone in the blank, Matrigel™ alone, monolayer rat mesenchymal stem cells (MSCs)/ Matrigel™, and MSC spheroids/ Matrigel™ groups were evaluated. In the blank group, the defect was left unfilled. (B) Quantitative results for micro-CT analysis. Healing of defects was shown as the fraction of new bone with respect to the total defect area as quantified by micro-CT analysis (n = 5 per group). There were statistical differences between the area of new bone formed in the MSC spheroids group and that in the other groups (p < 0.05). There are no significant difference in groups of gray columns jointed to horizontal bar.