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. Author manuscript; available in PMC: 2015 Jan 20.
Published in final edited form as: Nat Mater. 2007 Oct 28;7(1):52–56. doi: 10.1038/nmat2042

Figure 2. Design and synthesis of molecules to enable polymerization following a binding event.

Figure 2

Polymeric materials that are capable both of selective binding and of initiating a radical polymerization reaction subsequent to binding were synthesized according to this reaction. Initiators and proteins were linked to the –COOH groups of a high-molecular-weight copolymer of acrylic acid and acrylamide through ester linkages (initiators) and amide linkages (proteins). Though the acrylamide subunits were not involved in the conjugation reaction, their presence was important in the surface bound detection results shown in Figs 3 and 4 (macroinitiators made with an acrylic-acid starting material in the place of poly(acrylic acid-co-acrylamide) do not function similarly).