Table 3.
Univariate and multivariable Cox regression analysis of overall survival*
| Univariate analysis
|
Multivariable analysis†
|
|||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | |
| Age | 1·0 (0·9–1·0) | 0·47 | ·· | ·· |
|
| ||||
| Sex | ||||
| Men | 1·0 (reference) | 0·33 | ·· | ·· |
| Women | 1·3 (0·7–2·5) | ·· | ||
|
| ||||
| Histological type | ||||
| Intestinal | 1·0 (reference) | 0·63 | ·· | ·· |
| Diffuse | 1·1 (0·6–2·1) | ·· | ||
|
| ||||
| T | ||||
| T1–T2 | 1·0 (reference) | 0·001 | ·· | ·· |
| T3–T4 | 3·0 (1·5–6·0) | ·· | ||
|
| ||||
| N | ||||
| Negative | 1·0 (reference) | <0·0001 | ·· | ·· |
| Positive | 6·0 (2·3–15·5) | ·· | ||
|
| ||||
| Stage | ||||
| I–II | 1·0 (reference) | <0·0001 | 1·0 (reference) | <0·0001 |
| III–IV | 5·2 (2·5–10·6) | 4·3 (2·0–9·2) | ||
|
| ||||
| let-7g expression | ||||
| High | 1·0 (reference) | 0·003 | 1·0 (reference) | 0·002 |
| Low | 2·6 (1·3–4·9) | 2·9 (1·4–6·0) | ||
|
| ||||
| miR-214 expression | ||||
| Low | 1·0 (reference) | 0·007 | 1·0 (reference) | 0·004 |
| High | 2·4 (1·2–4·5) | 2·7 (1·3–5·6) | ||
|
| ||||
| miR-433 expression | ||||
| High | 1·0 (reference) | 0·015 | 1·0 (reference) | <0·0001 |
| Low | 2·1 (1·1–3·9) | 3·4 (1·7–6·6) | ||
|
| ||||
| let-7e expression | ||||
| High | 1·0 (reference) | 0·009 | ·· | ·· |
| Low | 2·2 (1·2–4·2) | ·· | ||
|
| ||||
| let-7i expression | ||||
| High | 1·0 (reference) | 0·039 | ·· | ·· |
| Low | 1·9 (1·0–3·5) | ·· | ||
*
One patient was censored before first event (patient’s death) and these data were removed.
†
For the final model of multivariable analysis, stage, let-7g, miR-214, and miR-433 were included.