Table 4.

Univariate and multivariable Cox regression analysis of disease-free survival^*

	Univariate analysis		Multivariable analysis†
	Hazard ratio (95% CI)	p	Hazard ratio (95% CI)	p
Age	1·0 (0·9–1·0)	0·63	··	··
Sex
Men	1·0 (reference)	0·31	··	··
Women	1·3 (0·7–2·5)		··
Histological type
Intestinal	1·0 (reference)	0·67	··	··
Diffuse	1·1 (0·6–2·1)		··
T
T1–T2	1·0 (reference)	0·001	··	··
T3–T4	3·1 (1·5–6·1)		··
N
Negative	1·0 (reference)	<0·0001	··	··
Positive	5·5 (2·1–14·2)		··
Stage
I–II	1·0 (reference)	<0·0001	1·0 (reference)	<0·0001
III–IV	4·5 (2·2–9·2)		5·2 (2·4–11·2)
let-7b expression
High	1·0 (reference)	0·003	1·0 (reference)	0·001
Low	2·7 (1·4–5·4)		3·2 (1·6–6·6)
let-7g expression
High	1·0 (reference)	0·002	1·0 (reference)	0·042
Low	2·7 (1·4–5·2)		2·0 (1·0–3·9)
miR-19a expression
High	1·0 (reference)	0·032	1·0 (reference)	<0·0001
Low	2·0 (1·0–3·6)		3·3 (1·7–6·5)
miR-495 expression
Low	1·0 (reference)	0·035	1·0 (reference)	0·007
High	1·9 (1·0–3·6)		2·4 (1·2–4·7)
miR-410 expression
Low	1·0 (reference)	0·016	··	··
High	2·2 (1·1–4·3)		··
miR-433 expression
High	1·0 (reference)	0·011	··	··
Low	2·1 (1·1–4·0)		··

^*No patients were censored before first event (disease recurrence).

^†For the final model of multivariable analysis, stage, let-7b, let-7g, miR-19a, and miR-495 were included.