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Comparison of model performance (weighted RMSE) between ElasticNet and the Ridge, LASSO, and SGSR algorithms. ElasticNet models are constrained to have a comparable number of features to the SGSR model. Each point corresponds to a single drug model. (A) CCLE with EXP (B) CCLE with COPY (C) Sanger with EXP (D) Sanger with COPY are applied for SGSR with 5 distinctive available pathway databases such as KEGG, BIOCARTA, Nature/NCI, GO_BP and GO_MF.
