Table 5.

The diagnostic values of a panel of three sputum miRNA (miRs-21, 31, and 210) biomarkers in an internal testing set and an external testing set of specimens

	An internal testing set of 122 patients with either malignant (n=67) or benign SPNs (n=69)	An external testing set consisting of 155 subjects with either malignant (n=76) or benign SPNs (n=79)
Sensitivity	82.09%	80.52%
Specificity	88.41%	86.08%
PPV (95% CI)	87.30% (76.89 to 93.42)	84.93% (74.99 to 91.37)
NPV (95% CI)	83.56% (73.43 to 90.34)	81.93% (72.30 to 88.73)

PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval.