Table 1. Proteomic analysis of Annexin A2/Atg16L+ vesicles.
| Atg16L/Annexin A2+ vesicles | Function | Reference |
|---|---|---|
| Actin | Vesicle trafficking | |
| Microtubule-actin cross-linking factor 1 | Vesicle trafficking | |
| Twinfilin | Modulator of Actin polymerization | |
| WAS/WASL interacting protein (WIPF1) | Modulator of Actin polymerization | |
| Coronin-1 | Autophagosome formation | 42 |
| Cortactin | Autophagosome–lysosomal fusion | 43 |
| Dynactin | Autophagosome movement | 44 |
| Cofilin 1 | Modulator of Actin polymerization | |
| AP-2 (beta and mu subunits) | Atg16L interaction | 7 |
| Clathrin | Atg16L interaction | 7 |
| Synaptotagmin II | Endocytosis | |
| Synaptojanin 2 | PI(4,5)P2 hydrolysis | |
| Endophilin A3 | Endocytosis; vesicular transport | |
| Annexin A2 | Lipid segregation (PS and PIs) | |
| Protein S100A11 | Annexin A2-binding partner | |
| ASAP2 | ARF6 regulator | |
| Vesicle-fusing ATPase | Vesicle trafficking | |
| ARF6 | PIP2 formation via PIP5K; PLD Inhibition | 6 |
| Girdin | Autophagy regulator | 30 |
| VAMP 7 | SNARE | 7 |
| VAMP 3 | SNARE | 5 |
| VtiB | SNARE | 7 |
| Ubiquitin | Binding to Atg16L | 45 |
| Galectin 3 | Endocytosis | |
| Aurora A kinase | Autophagy regulators | 31 |
| Vps 13c | Endocytosis; Regulation PI phosphates | |
| Hrb | VAMP 7 adaptor | 7 |
MA, macroautophagy; PI, phosphatidylinositol; PS, phosphatidylserine.
Proteins previously reported to be associated with MA are referenced.