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. 2014 Autumn;5(4):247–254.

Table 1.

Literature review of the effect of different types of Kisspeptin administration on the LH release in mammalian species

Species Sex Reproduction status Peptide type Route * Dose Reference
Cow Female Cycling Kisspeptin-10 IV 100 or 200 pmol kg-1  23 
Human Male Adult Kisspeptin-54 IV 4 pmol kg-1 per min, 90-min  27 
Human Male Adult Kisspeptin-10 IV 0.01-3.0 μg kg-1 46
Human Female Menstrual cycle Kisspeptin-54 SC 0.4 nmol kg-1  28 
Human Female Hypothalamic amenorrhea Kisspeptin-54 SC 6.4 nmol kg-1 twice daily for 2 week  4 7
Mouse Male Adult Kisspeptin-10
Kisspeptin-54		 ICV 1 fmol  15 
Mouse Male Adult Mouse kisspeptin 105-119 IP 100 μl of 10 μM  19 
Rat Male and female Adult Rodent kisspeptin-10 ICV 1 nmol  4 8
Rat Male Adult Kisspeptin-10 ICV/Peripheral 3 nmol  49 
Rat Male Adult Kisspeptin-54 ICV 1, 10 or 100 pmol 50
Rat Male Adult Rat kisspeptin-52 ICV 0.1 nmol 51
Rat Male Adult Rat kisspeptin-10
Human kisspeptin-10		 ICV 1 nmol 51
Rat Male Adult Rat kisspeptin-52 IV 10 nmol kg-1 51
Rat Male Adult Kisspeptin-10 IV 0.3 nmol kg-1  24 
Rat Male
Female		 Pre-puberty Metastin SC 100 nmol kg-1 (male)
6.7 nmol (female)		 52
Rat Female Cyclic, pregnant and lactating Kisspeptin-10 ICV 0.1 pmol - 1 nmol 53
Monkey Male Agonadal juvenile Human kisspeptin 45-54 10 μg 45
Monkey Male Adult Human kisspeptin 45-54 IV 200 or 400 μg per hr 54
Monkey Male Agonadal juvenile Kisspeptin-10 ICV/IV 30 μg or 100 μg  26 
Pig Male and female Pre-puberty Murine kisspeptin ICV/Peripheral 10 or 100 μg
1, 2.5, or 5 mg		  25 
Sheep Female Estradiol-treated ovariectomized Human kisspeptin 112-121 ICV 0.2 μg per min for 4 hr 19
Sheep Female Estradiol-treated ovariectomized Human kisspeptin-1 IV 6 nmol  21 
Sheep Female Anestrous season Murine kisspeptin-10 IV 12.4 nmol per hr, for 30 or 48 hr  21 
Sheep Female Breeding season Murine kisspeptin-10 IV 0.48 μmol per hr over 8 hr  21 
Sheep Female Anestrous season Kisspeptin-10 IV 15.2 nmol per hr 43
Goat Male Adult Kisspeptin-10 IV 5 µg kg-1 42
Goat Female Luteal phase Kisspeptin-10 IV 1, 5 and 10 μg kg-1 41
Welsh pony Female Cycling Human kisspeptin-10 IV 10 mg 55
Cow Female Pre-puberty Kisspeptin-10 IV 1 mg  22 
Cow Male and female Pre-puberty Kisspeptin-10 IV or IM 5 μg kg-1 56

SC: Subcutaneous; IV: Intravenous; IP: Intraperitoneal; IM: Intramuscular.

*

ICV: Intracerebroventricular;