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. 2014 Dec 3;7:213–221. doi: 10.1016/j.nicl.2014.12.002

Fig. 2.

Fig. 2

Changes in functional connectivity from the baseline resting state (‘REST’) to the allergen-evoked itch state (‘ITCH’). A. Seed-based functional connectivity from the right anterior insula (MNI coordinates: [30, 18, 1]). Top: Significant cluster in the left hippocampal formation (peak voxel coordinates: [−30, −44, −14] in the fusiform gyrus). Bottom: Significant cluster in the left posterior cingulate cortex (PCC) (peak voxel coordinates: [−12, −60, 14]). In each of the two panels, the graph on the left shows z-score levels of functional connectivity (main effect), in the resting state (‘REST’; white bar) and 15–17 min after allergen-based itch induction (‘ITCH’; black bar). The graph on the right shows for each scan session (N = 28) the difference in connectivity from ‘REST’ to ‘ITCH’ as a function of the difference in perceived itch intensity from ‘REST’ to ‘ITCH’, as reported by participants; linear regression across subjects is shown (red line) along with corresponding r and p values. B. Seed-based functional connectivity from the right anterior mid-cingulate cortex (coordinates: [8, 34, 28]), showing a significant cluster in the right putamen (peak voxel coordinates: [28, −12, 9]). C. Seed-based functional connectivity from the right globus pallidus (coordinates: [18, 4, 3]), showing a significant cluster in the left posterior mid-cingulate cortex (peak voxel coordinates: [−5, −25, 44]).