Table 1.

Seed-based functional connectivity results. For each seed, statistically significant clusters (with a cluster-forming threshold of Z > 2.3 and a cluster significance level of p < 0.05) are listed. For each cluster, the Z-value, MNI coordinates, and atlas label of the peak voxel are listed, along with Pearson's correlation coefficient r and corresponding p-value of the correlation with level of perceived itch.

Seed region	Z-value	X	Y	Z	Atlas label	Correlation with perceived itch
R premotor cortex	3.56	−9	−64.5	66	L precuneus	n.s.
	3.16	8	−48	61	R superior parietal lobule (5L)	n.s.
R insula	3.92	−30	−44	−14	L fusiform gyrus	n.s.
	3.81	−18	−36	−2	L parahippocampal gyrus	r = –0.39, p = 0.045
	3.61	−12	−60	14	L posterior cingulate cortex	r = –0.42, p = 0.025
	3.62	−52	−66	6	L middle temporal gyrus	n.s.
	3.38	−4	−18	40	L mid-cingulate cortex	n.s.
R putamen	3.78	−60	−20.5	22.5	Left postcentral gyrus	n.s.
	3.95	−61	−17.5	11	L transverse (or superior) gyrus, BA42	n.s.
	3.68	−2	−22	48	L medial frontal gyrus, BA6 or L paracentral lobule	n.s.
	4.01	−0.5	−35	41	L/R mid-cingulate cortex	n.s.
	3.35	−11	−41.5	29.5	L posterior cingulate cortex	n.s.
L superior parietal lobule	3.92	−53	−24.5	32	L inferior parietal lobule
	3.69	−41.5	29	27.5	L dlPFC (Middle frontal gyrus)	r = –0.40, p = 0.036
	3.61	43.5	−10.5	15	R posterior insula	n.s.
	4.24	29.5	−14	11.5	R putamen (not the same locus as the R putamen seed)	n.s.
R anterior mid-cingulate cortex	4.32	34	−21.5	10	R posterior insula	n.s.
	4.04	28.5	−12.5	9.5	R putamen	r = –0.40, p = 0.036
	4.03	58	−26.5	22	R inferior parietal lobule	n.s.
R caudate	4.39	−10.5	−73	23.5	L cuneus, BA18	n.s.
	3.86	−51.5	19.5	−4.5	L inferior frontal gyrus (pars orbitalis)	n.s.
R globus pallidus	3.98	−5	−25.5	44	L mid-cingulate cortex or paracentral lobule	r = –0.37, p = 0.050
	4.01	35.5	27	49	R superior/middle frontal gyrus (dlPFC)	n.s.