Table 1.
Baseline characteristics in the control, pituitary-dependent hyperadrenocorticism (PDH), and adrenal-dependent hyperadrenocorticism (ADH) groups
| Variables | Control ( n = 9) | PDH ( n = 10) | ADH ( n = 9) |
|---|---|---|---|
| Age (y/o) | 10.5 ± 2.8 | 12.5 ± 2.0 | 12.3 ± 2.0 |
| Body weight (kg) | 6.2 ± 2.7 | 4.5 ± 1.4 | 5.9 ± 2.7 |
| Female to male | 0.8 | 1 | 2 |
| Heart rate (bpm) | 128.9 ± 23.4 | 124.6 ± 16.8 | 129.3 ± 13.7 |
| Blood pressure (mmHg) | 134.6 ± 11.1 | 140.4 ± 11.0 | 156.2 ± 16.5‡† |
| Incidence of hypertension (%) | 0% | 10% | 56%‡† |
| LVEDD (mm) | 24.9 ± 3.8 | 23.6 ± 7.0 | 21.0 ± 4.8 |
| LVESD (mm) | 14.1 ± 2.8 | 12.9 ± 3.8 | 12.3 ± 3.1 |
| LVFWd (mm) | 4.9 ± 1.1 | 6.3 ± 1.0† | 6.4 ± 1.0† |
| IVSd (mm) | 5.1 ± 0.8 | 6.6 ± 1.2† | 7.1 ± 1.0‡† |
| Incidence of LVH (%) | 0% | 40%† | 56%† |
| LA/Ao ratio | 1.4 ± 0.1 | 1.5 ± 0.2 | 1.4 ± 0.2 |
| EF (%) | 75.4 ± 9.5 | 79.5 ± 5.6 | 75.0 ± 6.1 |
| FS (%) | 43.0 ± 8.0 | 46.1 ± 5.3 | 41.3 ± 5.1 |
| Mitral peak E wave (m/s) | 0.82 ± 0.33 | 0.63 ± 0.13 | 0.52 ± 0.20† |
| Mitral E/A ratio | 1.07 ± 0.35 | 0.94 ± 0.29 | 0.75 ± 0.38 |
| Tricuspid peak E wave (m/s) | 0.50 ± 0.16 | 0.41 ± 0.10 | 0.46 ± 0.23 |
| Tricuspid E/A ratio | 0.97 ± 0.31 | 0.94 ± 0.23 | 0.86 ± 0.43 |
| IVRT (mm) | 47.9 ± 8.7 | 57.4 ± 13.7 | 64.2 ± 20.3‡† |
| E/IVRT | 1.51 ± 0.34 | 0.92 ± 0.30† | 0.89 ± 0.42† |
Indices are presented as mean ± SD.
E/A ratio, early diastolic velocity/late diastolic velocity ratio; EF, ejection fraction; FS, fractional shortening; IVRT, isovolumetric relaxation time; IVSd, thickness of interventricular septum at end-diastole; LA/Ao, left atrial/aortic root ratio; LVEDD, left ventricular dimension at end-diastole; LVESD, left ventricular dimension at end-systole; LVFWd, thickness of left ventricular free wall at end-diastole, LVH, left ventricular hypertrophy.
† P < 0.05 relative to controls; ‡ P < 0.05 relative to PDH.