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. 2014 Dec 11;9:180. doi: 10.1186/s13000-014-0180-1

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© Liu et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Expressions of p16 ^INK4a , CRX and Ki67 in a representative RB case from RC group (100x). a. HE staining showed well-differentiated RC cells with typical fleurettes surrounded by moderately differentiated tumor cells; b. p16^INK4a was negative in the RC region, but positive in the surrounding tumor cells. A magnified image (insert) shows the transition zone between the RC and the tumor cells; c. CRX expression displayed the opposite pattern to that of p16^INK4a, being strongly positive in RC region but negative in the surrounding area; d. Ki67 expression was similar to that of p16^INK4a, with barely positive cells in RC region. All inserts, 200x.